CJC-1295

Compound identity

Each row above is attributed to its source. Rows citing a database record are reference information about the molecule; rows marked catalog information describe this listing. Neither is a specification, an analytical result or a claim about any particular batch.

Research classification

Synthetic analog of growth hormone-releasing hormone, GHRH(1-29). The long-acting form carrying a drug affinity complex (DAC) is the form described in the clinical literature under this name (Teichman et al., JCEM, 2006; PMID 16352683). Not an approved medicine.

Chemical characteristics

• The name covers two chemically distinct materials. "CJC-1295 with DAC" carries a Drug Affinity Complex moiety designed to bind covalently to serum albumin; "CJC-1295 without DAC" is the shorter modified GRF (1-29) peptide and does not.
• Because the DAC moiety adds substantial mass, the two forms are readily distinguished by mass spectrometry — which is the practical reason to confirm which form a batch actually contains.
• The molecular data recorded above corresponds to the DAC form as indexed in PubChem.

Analytical methods

• Reversed-phase HPLC (RP-HPLC) is the method most commonly used to express the chromatographic purity of a synthetic peptide as a percentage of total peak area at a stated wavelength.
• Mass spectrometry (typically ESI-MS or MALDI-TOF) is used to confirm that the observed mass of the material is consistent with the expected mass of the intended sequence.
• Because purity figures are method-dependent, an analytical result is only interpretable alongside the method conditions and the batch it describes.

Both methods are covered in more detail in our guides to HPLC analysis of peptides and mass spectrometry for identity confirmation.

Stability and storage considerations

• Lyophilized peptides are generally supplied as a dry solid because the removal of water slows hydrolytic degradation pathways.
• Cold, dry, light-protected storage is the general handling expectation for lyophilized research peptides.
• Once a peptide is taken into solution, its stability profile changes and is influenced by solvent, pH, temperature and the number of freeze-thaw cycles.
• Storage and handling expectations for a specific batch should be taken from that batch's documentation rather than from general guidance.

See peptide stability and degradation for the chemistry behind these considerations.

Frequently asked questions

What is the difference between CJC-1295 with DAC and without DAC?

They are different molecules. The DAC version carries an additional Drug Affinity Complex moiety intended to bind albumin; the non-DAC version, usually called modified GRF (1-29), does not. The mass difference is large enough that mass spectrometry distinguishes them straightforwardly.

Can I order CJC-1295 on its own from Peptide Tactics?

The current catalog lists CJC-1295 only as part of the combined CJC-1295 + ipamorelin vial. For availability questions, contact us directly.

What is CJC-1295 derived from?

It is a synthetic analog of growth hormone-releasing hormone, based on the first 29 residues of GHRH.

Sources

• PubChem CID 91971820 — CJC-1295

Related compounds

Further reading

• What are peptides? — A peptide is a chain of amino acids joined by amide bonds.
• Understanding peptide certificates of analysis — A certificate of analysis is a record of what was measured on a specific batch.
• Mass spectrometry and peptide characterisation — Chromatography tells you how many species are present.